Roybal Centers for Translational Behavioral Research on Dementia Care, Caregiver Support, and Prevention of Alzheimers Disease and Related Dementias (AD/ADRD) (P30 Clinical Trial Required) | RFA AG 24 007

Opportunity Information: Apply for RFA AG 24 007

The Roybal Centers for Translational Behavioral Research on Dementia Care, Caregiver Support, and Prevention of Alzheimers Disease and Related Dementias (AD/ADRD) funding opportunity (RFA-AG-24-007) is a National Institutes of Health (NIH) center grant (P30) designed to build and support research centers focused on creating and testing behavioral interventions that directly improve dementia care and caregiver support. The core idea is to move beyond basic or descriptive research and instead develop practical, principle-driven interventions that can be shown to work, refined for real-world settings, and positioned for broader implementation. The centers supported under this program are expected to function as hubs for translational intervention development research, meaning they should have the expertise and infrastructure to take promising behavioral strategies from early concept development through increasingly rigorous testing stages.

A major emphasis of the program is translational research structured around the NIH Stage Model (often described as Stage 0 through Stage IV). In practical terms, this means a funded Roybal Center should be prepared to run a pipeline of pilot studies that can include early foundational work (such as identifying intervention targets and mechanisms, tailoring approaches for specific caregiver or care settings, and developing protocols), followed by feasibility and refinement studies, and then progressing toward larger-scale efficacy and effectiveness testing and implementation-oriented work. The FOA highlights the expectation that centers will produce interventions that are not just theoretically interesting, but potent, implementable, and grounded in clear principles about how and why they work. The focus on multiple stages also signals that NIH is looking for centers that can support iterative development: building an intervention, testing it, learning from the data, and improving it so it can realistically be adopted by health systems, community organizations, and caregiver support infrastructures.

The scientific scope centers on dementia care and the people and systems that provide it. While the opportunity title includes prevention of AD/ADRD, the description places particularly strong weight on improving the health, well-being, and capacity of caregivers and care-providing systems for individuals living with Alzheimers disease and related dementias. That includes family and unpaid caregivers as well as formal caregivers, service providers, clinical teams, and organizations that deliver or coordinate dementia-related support. Interventions responsive to this FOA could reasonably target caregiver stress and mental health, caregiving skills, care coordination, communication, behavioral symptom management, adherence to care plans, reduction of caregiver burden, improving access to supportive services, or system-level practices that improve outcomes for both the person with dementia and the caregiver network. The intent is that behavioral interventions developed by these centers will be ready to translate into routine practice, rather than remaining confined to academic settings.

Administratively, this is a discretionary NIH grant in the health category, listed under CFDA 93.866, and it is explicitly labeled "Clinical Trial Required." That designation matters because applicants need to plan for and propose clinical trial activity consistent with NIH definitions, and they must be prepared to meet NIH clinical trial policies around registration, reporting, oversight, and human subjects protections. Because the mechanism is a P30 center grant, applicants typically need to demonstrate they have (or can build) shared resources, scientific leadership, governance, and an environment that supports multiple related pilot projects and developmental studies rather than a single stand-alone research project.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments that are federally recognized; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in those specific nonprofit categories); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly calls out additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it draws clear boundaries around foreign involvement: non-U.S. entities and non-U.S. components of U.S. organizations are not eligible to apply, though foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed. In other words, the applicant organization must be eligible and primarily U.S.-based, but certain kinds of foreign collaboration may be permissible if structured as an allowable foreign component.

In terms of funding parameters, the listed award ceiling is $750,000. The opportunity record shows an original closing date of 2023-06-23 and a creation date of 2023-03-03. The expected number of awards is not specified in the provided source text. Overall, the program is aimed at creating sustained, center-based capacity to generate high-quality behavioral interventions for dementia caregiving and care systems, with the explicit expectation that funded centers will carry out a range of staged pilot clinical studies that move interventions toward real-world impact.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Roybal Centers for Translational Behavioral Research on Dementia Care, Caregiver Support, and Prevention of Alzheimers Disease and Related Dementias (AD/ADRD) (P30 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2023-03-03.
• Applicants must submit their applications by 2023-06-23. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $750,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA AG 24 007

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