Opportunity Information: Apply for PAR 19 045
The grant opportunity titled "End-of-Life and Palliative Care Approaches to Advanced Signs and Symptoms (R01 Clinical Trial Optional)" (Funding Opportunity Number PAR 19 045) is a discretionary National Institutes of Health (NIH) research grant designed to advance knowledge about difficult, complex symptoms that occur in the final stages of serious illness. The central aim is to stimulate research that looks closely at the multi-dimensional foundations of advanced signs and symptoms near the end of life, how patients and families experience them, and how clinicians and care teams can manage them more effectively. In practical terms, this FOA is interested in improving how end-of-life and palliative care addresses severe, often overlapping symptom burdens, including physical, psychological, social, and potentially spiritual dimensions, with the goal of generating evidence that can translate into better care and quality of life for people nearing the end of life.
A defining feature of this opportunity is its focus on "complex, advanced" symptoms, meaning symptoms that are not straightforward, may cluster together, may worsen unpredictably, and often occur in the context of advanced disease and declining function. Research supported by this FOA is expected to examine the underlying mechanisms or contributors to these symptoms (for example, biological, behavioral, environmental, care-delivery, or contextual drivers), document and interpret lived experiences for patients and caregivers, and test or refine approaches to symptom management in real-world end-of-life settings. Because the announcement emphasizes multi-dimensional foundations and experiences, it encourages work that does not treat symptoms as isolated problems, but instead considers how multiple symptoms interact, how they are shaped by care settings and social circumstances, and how care strategies can be tailored to patient goals and needs.
The mechanism is an R01, which generally supports substantial, hypothesis-driven or well-structured programs of research. The listing "Clinical Trial Optional" signals that applicants may propose studies that include clinical trials, but they are not required to do so. That flexibility allows for a wide range of study designs, including observational research, measurement and assessment work, intervention development and testing, pragmatic studies in clinical practice, and trials when appropriate. The funding instrument type is a grant, and the activity category is listed under education and health (CFDA number 93.361), reflecting NIHs role in supporting research that improves health outcomes and care delivery. The source data does not specify an award ceiling or the number of expected awards, which typically means applicants should consult the full FOA details and NIH budget guidance to understand allowable budgets, project periods, and institute-specific expectations.
Eligibility is broad and includes many types of U.S. organizations and institutions that commonly apply for NIH research funding. Eligible applicants include state, county, city or township governments, special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, Native American tribal governments (federally recognized), public housing authorities and Indian housing authorities, and Native American tribal organizations other than federally recognized tribal governments. Nonprofit organizations are eligible whether or not they have 501(c)(3) status, provided they are not institutions of higher education. For-profit organizations other than small businesses, as well as small businesses, are also listed as eligible, along with an "other" category that may cover additional entity types permitted under NIH rules.
Beyond the standard eligibility list, the FOA explicitly highlights additional eligible applicants to encourage diverse institutional participation and broaden the settings and populations involved in end-of-life and palliative care research. These include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). It also includes eligible federal government agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and Indian/Native American tribal governments other than federally recognized entities. Notably, the FOA also allows non-domestic (non-U.S.) entities (foreign organizations) to apply, which can support cross-national collaboration or research in settings where end-of-life care challenges and models of care differ, as long as the project aligns with NIH requirements and the FOAs scientific goals.
From a timing standpoint, the FOA was created on 2018-10-31, and the source data lists an original closing date of 2022-01-07. In many NIH announcements, application due dates may occur in cycles or may be updated through reissues, so anyone planning to apply would need to verify the current status of the opportunity, whether it remains active, and what the next submission dates are through the NIH and Grants.gov posting for PAR 19 045 or any successor announcement.
Overall, this grant is aimed at pushing the science of end-of-life symptom understanding and management forward by supporting rigorous research that reflects the real complexity of advanced illness. It is designed to generate actionable knowledge about why severe symptoms happen and persist, how they are experienced by patients and caregivers, and what care strategies are most effective and feasible in palliative and end-of-life contexts, with room for both non-trial and clinical trial approaches depending on the research question.Apply for PAR 19 045
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "End-of-Life and Palliative Care Approaches to Advanced Signs and Symptoms (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361.
- This funding opportunity was created on 2018-10-31.
- Applicants must submit their applications by 2022-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: End-of-Life and Palliative Care Approaches to Advanced Signs and Symptoms (R01 Clinical Trial Optional) (PAR-19-045)
What is the main purpose of this grant opportunity?
This NIH discretionary research grant supports studies that advance knowledge about difficult, complex signs and symptoms that occur in the final stages of serious illness. The goal is to generate evidence that can translate into better end-of-life and palliative care and improved quality of life for patients nearing the end of life.
What kinds of symptoms is the FOA focused on?
The focus is on "complex, advanced" symptoms near the end of life, including severe and often overlapping symptom burdens. The FOA emphasizes that these symptoms may cluster together, worsen unpredictably, and occur alongside advanced disease and declining function. It also highlights multi-dimensional symptom burdens that can include physical, psychological, social, and potentially spiritual dimensions.
What does the FOA mean by "multi-dimensional foundations" of symptoms?
It refers to the idea that advanced symptoms are not driven by a single factor. Supported research is expected to look at underlying mechanisms or contributors such as biological, behavioral, environmental, care-delivery, or contextual drivers, and to consider how symptoms interact with each other and with the patient’s setting and circumstances.
Is this opportunity only about treating symptoms, or also about understanding them?
It supports both. The FOA is interested in research that explains why severe symptoms happen and persist (mechanisms and contributors), documents and interprets lived experiences for patients and caregivers, and tests or refines approaches to symptom management in real-world end-of-life settings.
How does the FOA want researchers to think about symptoms?
The announcement encourages approaches that do not treat symptoms as isolated problems. It emphasizes how multiple symptoms may interact, how symptoms are shaped by care settings and social circumstances, and how management strategies can be tailored to patient goals and needs.
What is the grant mechanism and what does it imply?
The mechanism is an NIH R01. An R01 typically supports substantial, well-structured, hypothesis-driven (or otherwise rigorous) programs of research, which can include complex study designs and multi-aim projects aligned with the FOA's scientific goals.
What does "Clinical Trial Optional" mean for applicants?
It means applicants may propose studies that include clinical trials, but they are not required to do so. This allows a broad range of designs, from non-interventional research through to trials when appropriate for the research question.
What kinds of study designs are encouraged or allowed under this FOA?
Based on the description, the FOA allows and supports a range of designs, including observational studies, measurement and assessment work, intervention development and testing, pragmatic studies in clinical practice, and clinical trials when appropriate.
What settings does the FOA consider relevant for research?
The FOA emphasizes real-world end-of-life settings and recognizes that care settings and social circumstances shape symptom experience and management. It encourages research that reflects the complexity of advanced illness as it is encountered in practice.
Who are the primary populations of interest?
People nearing the end of life who experience severe, complex symptom burdens are central, along with families and caregivers who experience and manage these symptoms alongside patients. The FOA also reflects the role of clinicians and care teams who deliver end-of-life and palliative care.
What types of organizations are eligible to apply?
Eligibility is broad and includes many U.S. organization types commonly eligible for NIH funding, such as state/county/city/township governments, special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, Native American tribal governments (federally recognized), public housing authorities, and Indian housing authorities.
Are nonprofits eligible, and do they need 501(c)(3) status?
Nonprofit organizations are eligible whether or not they have 501(c)(3) status, as long as they are not institutions of higher education (as stated in the eligibility summary provided).
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses, as well as small businesses.
Are tribal organizations eligible even if they are not federally recognized governments?
Yes. The eligibility description includes Native American tribal organizations other than federally recognized tribal governments, and it also highlights eligibility for Indian/Native American tribal governments other than federally recognized entities.
Are U.S. territories or possessions eligible?
Yes. The FOA explicitly includes U.S. territories or possessions among the highlighted eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal government agencies are included among the highlighted eligible applicants.
Can faith-based or community-based organizations apply?
Yes. Faith-based or community-based organizations are explicitly listed among the highlighted eligible applicants.
Are minority-serving institutions specifically encouraged or eligible?
Yes. The FOA highlights and encourages participation from several categories of institutions, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are non-U.S. (foreign) organizations allowed to apply?
Yes. The FOA allows non-domestic (non-U.S.) entities (foreign organizations) to apply, which can support cross-national collaboration or research in different end-of-life care contexts, as long as NIH requirements and the FOA’s scientific goals are met.
What is the CFDA number and the general category of this program?
The CFDA number listed is 93.361, and the activity category is described under education and health, consistent with NIH’s role in supporting research that improves health outcomes and care delivery.
Does the provided information state an award ceiling or the number of awards?
No. The source information does not specify an award ceiling or the number of expected awards. Applicants would typically need to consult the full FOA text and NIH budget guidance for details on allowable budgets, project periods, and institute-specific expectations.
When was this FOA created and what closing date is shown in the source information?
The FOA was created on 2018-10-31. The source data lists an original closing date of 2022-01-07.
Is the closing date final, or could the opportunity still be active?
The description notes that NIH announcements may have due dates in cycles or may be updated through reissues. Anyone planning to apply would need to confirm the current status, whether it remains active, and the next submission dates by checking the NIH and Grants.gov posting for PAR-19-045 or any successor announcement.
What kinds of outcomes is NIH hoping to achieve through this research?
The FOA aims to produce actionable knowledge about advanced symptom burden near the end of life: why severe symptoms occur and persist, how they are experienced by patients and caregivers, and what management strategies are most effective and feasible in palliative and end-of-life care contexts.
How does this FOA relate to care teams and clinical practice?
It explicitly includes interest in how clinicians and care teams can manage complex symptoms more effectively, and it supports work that tests or refines symptom management approaches in real-world end-of-life settings.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is PAR-19-045.
What is the official title of the opportunity?
The opportunity is titled "End-of-Life and Palliative Care Approaches to Advanced Signs and Symptoms (R01 Clinical Trial Optional)."
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